Family history–based colorectal cancer screening in Australia: A modelling study of the costs, benefits, and harms of different participation scenarios

M Dillon; L Flander; DD Buchanan; FA Macrae; JD Emery; IM Winship; A Boussioutas; GG Giles; JL Hopper; MA Jenkins; D Ait Ouakrim

Journal article

Family history–based colorectal cancer screening in Australia: A modelling study of the costs, benefits, and harms of different participation scenarios

M Dillon, L Flander, DD Buchanan, FA Macrae, JD Emery, IM Winship, A Boussioutas, GG Giles, JL Hopper, MA Jenkins, D Ait Ouakrim

Plos Medicine | PUBLIC LIBRARY SCIENCE | Published : 2018

DOI: 10.1371/journal.pmed.1002630

Download PDF

Abstract

Background: The Australian National Bowel Cancer Screening Programme (NBCSP) was introduced in 2006. When fully implemented, the programme will invite people aged 50 to 74 to complete an immunochemical faecal occult blood test (iFOBT) every 2 years. Methods and findings: To investigate colorectal cancer (CRC) screening occurring outside of the NBCSP, we classified participants (n = 2,480) in the Australasian Colorectal Cancer Family Registry (ACCFR) into 3 risk categories (average, moderately increased, and potentially high) based on CRC family history and assessed their screening practices according to national guidelines. We developed a microsimulation to compare hypothetical screening sce..

View full abstract

University of Melbourne Researchers

Louisa Flander Author

Daniel Buchanan Author

Finlay Macrae Author

Jon Emery Author

Related Projects (2)

CENTRE OF RESEARCH EXCELLENCE FOR REDUCING THE BURDEN OF COLORECTAL CANCER BY OPTIMISING SCREENING:EVIDENCE OF CLINICAL PRACTICE

Bowel cancer, the second most diagnosed and cause of cancer death is preventable. Low risk people need no screening or just inexpensive feca..

PRECISION PUBLIC HEALTH FOR MAJOR CANCERS - NOVEL APPROACHES TO BUILDING THE GENETIC, EPIGENETIC AND LIFESTYLE KNOWLEDGE BASE FOR ASSESSING RISK AND PROGNOSIS

The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by grant UM1 CA167551 from the National Cancer Institute, National Institutes of Health (NIH), and by the National Health and Medical Research Council (NHMRC) Centre for Research Excellence grant APP1042021 and program grant APP1074383, Australia. No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.